ANTI-TUMOR EFFECT OF AMINO ACID RELATED COMPOUNDS (2) BODY-DISTRIBUTION AND TOXICITY OF ANTI-TUMOR AMINO ACID RELATED COMPOUNDS

Synthesis, anti-tumor and anti-angiogenic activity evaluations of asiatic Acid amino Acid derivatives.

Fifteen semi-synthetic derivatives of asiatic acid (AA) have been synthesized and evaluated for their biological activities. The successful modification of these compounds at the C-2, C-3, C-23 and C-28 positions was confirmed using NMR, MS and IR spectra. Further, their anti-tumor effects were evaluated in vitro using different cancer cell lines (HeLa, HepG2, B16F10, SGC7901, A549, MCF7 and PC...

The Anti-tumor Activity of 2-keto-3-ethoxybutyraldehyde Bis(thiosemicarbazone) and Related Compounds.

2-Keto-3-ethoxybutyraldehyde bis(thiosemicarbazone) (KTS) has been shown to have marked carcinostatic and carcinolytic activity against several established rat tu mors. Dose-response relationships have been established for its toxicity, tumor-in hibitory activity, and capability of causing regressions. The compound is more safely administered via the oral route than by intraperitoneal injection...

the evaluation of language related engagment and task related engagment with the purpose of investigating the effect of metatalk and task typology

abstract while task-based instruction is considered as the most effective way to learn a language in the related literature, it is oversimplified on various grounds. different variables may affect how students are engaged with not only the language but also with the task itself. the present study was conducted to investigate language and task related engagement on the basis of the task typolog...

Pteroylglutamic acid and related compounds.

Acid hydrolysis of colchicine and related compounds.

Acid-catalyzed hydrolysis of the methox-ytropone moiety of colchicine has been shown to proceed at a greater rate than in the case of isocolchicine1. (Struc­ tures are shown in Table I.) No interpretation of this rate difference has been offered. And, while a mecha­ nism for the acid-catalyzed hydrolysis of 2 -methoxytropone has been proposed2, no kinetic data on this type of reaction either fo...